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Webinar: Computational investigations of immune response to repeated influenza infections/vaccinations

You are invited to participate in an online webinar titled “Computational investigations of immune response to repeated influenza infections and vaccination” by Dr. Emmanuel S. Adabor who is a lecturer of Mathematics at GIMPA. You will have the opportunity to interact with him as well as other experts in the field.

Register here to receive information on how to join  the call. You must register for the webinar in order to join.

Date: Wednesday February 21st, 2018

Time: 3:00pm GMT (10:00 EST)

Contact email: George.Acquaah-Mensah@mcphs.edu

Speaker:

Dr. Emmanuel S. Adabor
GIMPA

Abstract:
The human immune response to natural infections/vaccinations sometimes produces counterintuitive outcomes; repeated infections/vaccinations with similar viruses rather than being more protective are sometimes actually deleterious. Why is this the case? As the immune response is an emergent property of a complex system –the immune system –it is best studied using empirically grounded mathematical modelling. In this talk, we  shall use a novel mathematical model to investigate the causes of a particularly troubling observation: in many cases, people who receive more vaccines against related influenza viruses are much more likely to catch the flu than those who receive fewer vaccines. We shall show that this is the dynamic consequence of interactions between vaccines, influenza viruses, and specific immune cells. In addition, we shall elucidate the precise characteristics of the vaccine/infecting viruses that make repeated infection/vaccination detrimental. The results have the potential to inform vaccination policy for influenza and other variable pathogens.